Autonomy begins after the problem has been chosen, and choosing it is a human act. A vast space of possible targets, diseases, and mechanisms exists, but only some are worth pursuing. That selection rests on patient need, prior evidence, feasibility, and values about who should benefit — none of which can be read off a dataset. AI can rank and estimate within a defined space, but it cannot decide which space deserves the effort.
Can AI Run a Drug Discovery Lab on Its Own?
What Still Needs a Human
Choosing the Problem
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Think back to the anomaly that stalled the loop. Before any of that machinery runs, someone has to decide which problem is even worth attacking.
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