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How Viruses Enter Cells, Replicate, and Evade Immunity

1Viral Architecture and the Logic of the Life Cycle2Attachment and Entry: Crossing the Membrane3Genome Replication and Gene Expression4Assembly, Egress, and Transmission5Innate Immune Detection of Viral Infection6Adaptive Immunity: Antiviral Antibodies and T Cells7Immune Evasion Strategies8From Mechanism to Intervention: Antivirals and Vaccines
Viral Architecture and the Logic of the Life Cycle

What a Virion Is Made Of

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Start with the innermost layer. The genome is the cargo, and the capsid around it is a shell built from many copies of a few proteins, which is why viruses can encode a large structure with very little genetic space. The capsid protects the genome outside the cell and helps release it once inside. Now look at the outer ring. If the virion has an envelope, it is a piece of stolen host membrane, and the spikes on it are viral glycoproteins that do the receptor binding and the membrane fusion. Notice that the envelope is lipid, so it is fragile compared with a bare capsid. Finally, some particles carry a polymerase inside. Hold that thought, because whether a virus needs to package an enzyme is decided entirely by its genome type.
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A virion is a nucleic acid genome packaged inside a protein shell called the capsid. The capsid is not a passive container: it protects the genome from nucleases and from physical damage outside the cell, and in many viruses it also participates in recognizing the target cell and in releasing the genome once inside. Capsids are built from repeating protein subunits, which is why a small number of genes can produce a large, symmetrical shell.

Many viruses add a second layer: a lipid envelope borrowed from a host cell membrane, studded with viral glycoproteins. These glycoproteins are the attachment and fusion machinery — the parts that bind a receptor and later merge the viral membrane with a cellular membrane. Because the envelope is a lipid bilayer, enveloped viruses are sensitive to detergents, drying, and heat in ways that non-enveloped viruses are not.

Some virions also carry enzymes inside the particle. The most important is a polymerase, the enzyme that copies nucleic acid. Whether a virus needs to package one depends entirely on its genome type, which is the subject of the next page.

A useful way to hold this together: the capsid and envelope are the delivery system; the genome is the cargo; any packaged enzymes are tools the virus cannot make after entry because it has no ribosomes of its own.

Referências

  1. [1]Structure and Classification of Viruses — Medical Microbiology, NCBI Bookshelfncbi.nlm.nih.gov
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