A safety signal is a pattern in the data that stands out enough to deserve a closer look. It is not a proven harm, and treating it as one would be a mistake. What continuous monitoring does is raise the pattern to attention early, while the evidence is still thin and the situation can still be investigated cheaply.
The diagram shows a stream of measurements plotted over time against an expected range. Most points sit inside the range. At some point, several points begin to cluster above the upper boundary — not a single dramatic spike, but a sustained drift. The threshold line marks where the accumulated evidence crosses from ordinary variation into something worth flagging. The flag does not say what is wrong. It says: this pattern is unusual enough that a person should look at it now rather than at the next scheduled review.